FAQ &
How To Use

Frequently Asked Questions

What is so unique about the CleanWash™ bottle?

The CleanWash has a very unique (patent pending) design. It utilizes two valves: one for liquid and one for air to prevent backwash contamination. The bottom of the CleanWash is removable to allow for easy cleaning and complete drying after use to minimize bacteria colonization.

What is Chitosan?

Chitosan is an amazing molecule. What superfoods are to the nutrition world, chitosan is to the immune world! It is the second most abundant polysaccharide (complex sugar) on earth. Cellulose is the most abundant. We use a plant based chitosan product.It is completely natural, and biodegradable. It has known anti-fungal and anti-bacterial properties (1,2). Why even have this: When applied (to wounds), chitosan effectively stops bleeding.(Using chitosan in the nose with ChitoRhino will not affect clotting in your body or affect any blood thinning agents you may be on.)

How is Chitosan Used?

Chitosan is used in pharmaceutical formulations and dietary supplements for weight loss, hyperlipidemia, and wound healing. It is also made into an edible film to protect food from spoilage (4). Also, Intense studies are underway by large pharmaceutical companies to use chitosan as a drug carrier for delivery via nasal sprays.

Why Use Chitosan in a Nasal and Sinus Rinse?

ChitoRhino is a nasal and sinus wash. As with any nasal and sinus wash, the solution has to be compatible with the nasal lining. ChitoRhino is a soothing, ph-balanced saline solution infused with chitosan. ChitoRhino™ is a combination of medically proven saline irrigation with the clinically proven benefits of chitosan.

What Happens When Chitosan is Placed on the Nasal Lining or Skin Surface?

Studies in the sinuses demonstrate that chitosan gel placed after sinus surgery reduces scarring (5,6). Chitosan gels have also been studied to treat burn wounds (7,8). Topical application enhances wound healing by stimulation of granulation tissue (normal healing tissue). Possible mechanisms of action include formation of a gel-like fibronectin matrix that facilitates inward epithelial cell migration and the formation of heparin-chitosan complexes that ultimately activates growth factors that bind to stabilized heparin (9).

Recent research has also demonstrated that chitosan can disrupt bacterial biofilms. Biofilms are a “glue” that mat bacteria and fungi together and make them very difficult to eliminate. Biofilms are thought to be a leading cause of chronic and recalcitrant (difficult to treat) sinusitis. Chitosan’s natural properties allow it to disrupt biofilms. This may have a significant impact on the treatment of sinusitis.

What Happens to Chitosan in the Body?

Chitosan has a known metabolic pathway. After entering the body any leftover chitosan is broken down by the normal enzymes in the body. Chitosan is digested by lysozyme, a human enzyme which is present in tears, saliva and mucus. It breaks down to glucosamine (a sugar which is already present in the body that helps lubricate joints) (10). In fact, many forms of glucosamine are derived from chitosan. Once ingested chitosan forms a positively charged gel matrix in stomach acid enabling it to bind bile acids and cholesterol (11).

What Medical Benefits Does Chitosan Offer?

Chitosan may lower bad cholesterol (LDL) (11,12). One small study in obese patients found that chitosan supplementation decreased weight, body mass index, waist circumference, and triglycerides (13). A systematic review of the published literature also concluded that chitosan reduced total cholesterol (14). Chitosan may increase total plasma antioxidant activity and lower indices of oxidative stress in humans (15,16).

What Are Some Other Facts About Chitosan?

Chitosan is used widely in medical bandages, diet aids and some cosmetics. It is an approved food ingredient and generally recommended as safe (GRAS) by the FDA.

What Are Some Other Uses of Chitosan?

Chitosan also has many commercial uses. It can be used in agriculture as a seed treatment to help plants fight off fungal infections. In winemaking it can be used as a fining agent to help prevent spoilage. Chitosan is commonly used as a water-filtering agent.

How To Use

Why ChitoRhino?

Our entire nasal and sinus care product line features chitosan. Chitosan is a remarkable all natural molecule with clinically proven anti-bacterial, anti-fungal, anti-inflammatory, and anti-viral properties.

ChitoRhino is the only nasal and sinus care product infused with chitosan.

Why CleanWash?

Did you know 97% of nasal and sinus rinse bottles are contaminated with staph aureus after 1 week of use?*

It’s the ONLY nasal and sinus rinse bottle with two valves and a removable bottom. The valves eliminate backwash contamination. The removable bottom allows for easy cleaning and drying to prevent bacterial biofilm formation. See our video here.

*The clinical significance of nasal irrigation bottle contamination. Laryngoscope. 2010 Oct;120(10):2110-4

What can I expect when I use ChitoRhino and the CleanWash bottle?

Our products have been designed and developed by a leading ENT surgeon. Our primary focus is to provide the most advanced products available to improve your sinus and nasal care. Many customers prefer our nasal rinse over leading brands because they find it much more soothing. We use a special ratio of ingredients to ensure maximal comfort during irrigation.

Since we employ dual valve technology, our CleanWash may seem a little less compliant than other leading brands. The valves need the right mix of “give and bounce” to prevent backwash. A few tips may help: First, fill the bottom of the CleanWash with a small amount of hot water (distilled/sterile or previously boiled). You can then swirl the hot water around the bottle to soften the plastic. Then place your ChitoRhino in the bottle and then complete the filling of the bottle with water (room air temperature). You may also fill your bottle as directed and heat in the microwave in 5 second intervals.

It is generally recommended that you use warm water to maximize comfort during the rinsing process. If the solution is too hot for the back of your hand, it is too hot for your nose.

Never use untreated tap water in any nasal rinse bottle or neti-pot.

ALL of the solution may not come out of the bottle. A small amount of solution may remain in the bottle after irrigation. This is OK. Trying to get every last bit of solution out will deform the side walls and the bottom cap may “pop” off.

Why a removable bottom?

Bacteria love a wet environment. Current leading nasal and sinus rinse bottle designs employ narrow neck designs. This design feature makes for difficult cleaning and drying after use.

The CleanWash™ bottle employs large openings at the top and bottom. And the removable bottom allows for easy cleaning and complete drying between uses – elimination of moisture maximizes sanitation.

No liquid coming out?

Not a problem. Since the CleanWash bottle has a top and bottom, there may be a chance that one of the caps is not on tight enough. There does have to be a complete seal so air does not escape. Also, make sure the “o” rings are in place in the top and bottom cap.

Who can use our products?

Our products are safe for children 4 years above, pregnant and nursing mothers and adults.

Cleaning?

It’s nice to have a best in class product 🙂 97% of leading nasal rinse bottles on the market today are contaminated with staph aureus after 1 week of use (see #2 above). In fact, the leading brand contains a “warning” about cleaning. The CleanWash bottle was designed to minimize contamination and maximize ease of cleaning. You can clean the CleanWash bottle like you would any other dish you might have in the house. First, unscrew the bottom. Next unscrew the top. Remove the soft silicon tip and the inner tube for the liquid. Then you simply clean with warm soapy water and pat dry. In most instances the next time you rinse, the caps and bottle will be dry. You may also clean by placing the bottle on the top rack of the dishwasher. The bottom and top cap can be placed in the utensil holder. Ensure you don’t lose the “o” rings in the top and bottom cap.

Performing these steps ensures ZERO bacterial growth in the bottle. (data on file)

What type of water should I use?

Does it really matter what type of water I use? Yes it does! We employ best practices for our design and instructions for use of the CleanWash bottle.

According to the FDA…. “Most important is the source of water that is used with nasal rinsing devices. Tap water that is not filtered, treated, or processed in specific ways is not safe for use as a nasal rinse.Some tap water contains low levels of organisms, such as bacteria and protozoa, including amoebas, which may be safe to swallow because stomach acid kills them. But these “bugs” can stay alive in nasal passages and cause potentially serious infections, according to the Centers for Disease Control and Prevention (CDC).” (http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm316375.htm)

While infection from tap water is rare, we along with the FDA recommend NOT using untreated tap water.

Color & Consistency

Chitosan is a naturally derived product. Since it is all-natural, you may notice occasional changes in color or consistency between batches. You may notice clumping as well.

1 – Aziz MA. Antimicrobial properties of a chitosan dextran-based hydrogel for surgical use. – – Antimicrob Agents Chemother – 01-JAN-2012; 56(1): 280-7.

2 – Altiok D – J Mater. Physical, antibacterial and antioxidant properties of chitosan films incorporated with thyme oil for potential wound healing applications. – Sci Mater Med – 01-JUL-2010; 21(7): 2227-36.

4 – Cagri A, Ustunol Z, Ryser ET. Antimicrobial edible films and coatings. J Food Prot. 2004 Apr;67(4):833-48.

5 – Athanasiadis T. Effects of a novel chitosan gel on mucosal wound healing following endoscopic sinus surgery in a sheep model of chronic rhinosinusitis. – – Laryngoscope – 01-JUN-2008; 118(6): 1088-94

6 – Medina JG. A chitosan-based sinus sealant for reduction of adhesion formation in rabbit and sheep models. – Otolaryngol Head Neck Surg – 01-AUG-2012; 147(2): 357-63

7 – Ribeiro MP. Development of a new chitosan hydrogel for wound dressing. – Ribeiro MP – Wound Repair Regen – 01-NOV-2009; 17(6): 817-24 .

8 – Alsarra IA. Chitosan topical gel formulation in the management of burn wounds. – Alsarra IA – Int J BiolMacromol – 1-JUL-2009; 45(1): 16-21.

9 – Stone CA, et al. Healing at skin graft donor sites dressed with chitosan. Br J PlastSurg2000;53:601-6.

10 – Aiba S. Studies on chitosan: Lysozymic hydrolysis of partially N-acetylated chitosans. Int J BiolMacromol. 1992 Aug;14(4):225-8.

11 – Maezaki Y, et al. Hypocholesterolemic effect of chitosan in adult males. Biosci Biotech Biochem1993;57:1439-44.

12 – Tai TS, et al. Effect of chitosan on plasma lipoprotein concentrations in type-two diabetic subjects with hypercholesterolemia. Diabetes Care 2000;23:1703-4.

13 – Hernández-González SO, González-Ortiz M, Martínez-Abundis E, et al. Chitosan improves insulin sensitivity as determined by the euglycemic-hyperinsulinemic clamp technique in obese subjects. Nutr Res. 2010 Jun;30(6):392-5.

14 – Baker WL, Tercius A, Anglade M, et al. A meta-analysis evaluating the impact of chitosan on serum lipids in hypercholesterolemic patients. Ann NutrMetab. 2009; 55(4):368-74.

15 – Anraku M, Fujii T, Furutani N, et al. Antioxidant effects of a dietary supplement: reduction of indices of oxidative stress in normal subjects by water-soluble chitosan. Food ChemToxicol. 2009 Jan;47(1):104-9.

16 – Pittler MH, et al. Randomized, double-blind trial of chitosan for body weight reduction. Eur J ClinNutr1999;53:379-81.